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. Author manuscript; available in PMC: 2019 Feb 26.
Published in final edited form as: JAMA Psychiatry. 2015 Jul;72(7):714–726. doi: 10.1001/jamapsychiatry.2015.0111

Figure 2. Estradiol Withdrawal Precipitation of Depressive Symptoms.

Figure 2.

Women with past perimenopausal depression (PMD) randomized to placebo (but not those randomized to estradiol and control women randomized to either estradiol or placebo) had significantly increased (ie, more symptomatic) Center for Epidemiologic Studies-Depression Scale (CES-D) scores compared with scores during the open-label administration of estradiol. In addition, CES-D scores in women with PMD during use of placebo were significantly increased compared with the scores of both control women randomized to placebo and those with past PMD randomized to estradiol. The dosage of estradiol used throughout the study was 100 μg/d. Data markers indicate the arithmetic mean; error bars, SE.