Table 2.
Genetic variants associated with PDA
| Gene | SNP ID | Major Allele | MAF* | N | aOR | p-value |
|---|---|---|---|---|---|---|
| EPAS1 | rs3088359 | C | T=0.46 | 961 | 1.64 | 0.00036 |
| PTGIS | rs1502245 | A | G=0.38 | 956 | 1.47 | 0.00054 |
| PGPEP1L | rs1521484 | C | G=0.44 | 940 | 1.45 | 0.0028 |
| IGF1 | rs5742627 | G | A=0.009 | 934 | 0.616 | 0.0044 |
| EDN1 | rs5370 | G | T=0.25 | 961 | 0.533 | 0.0045 |
| EPAS1 | rs17035091 | C | G=0.09 | 960 | 2.317 | 0.0046 |
| NRG1 | rs16879773 | G | A=0.13 | 961 | 0.513 | 0.0053 |
| LRP4 | rs2306036 | T | C=0.33 | 959 | 0.69 | 0.0064 |
| EPAS1 | rs11690950 | A | G=0.43 | 959 | 0.693 | 0.0076 |
| NOS2 | rs6505469 | A | T=0.37 | 946 | 1.39 | 0.0082 |
| FLT1 | rs7332329 | G | A=0.42 | 961 | 1.38 | 0.0084 |
| ABCA4 | rs1931566 | G | C=0.17 | 960 | 1.84 | 0.0085 |
*
Minor allele frequency from 1000 Genomes in European Samples
N= Sample size genotyped
aOR= Adjusted odds ratio