Table 1.
Characteristics by Surgical Treatment - Clinical T3 patients a n(%)
| BCT (N =2,927) | Mtx (N = 16,502) | Total (N = 19,429) | P-value* | ||
|---|---|---|---|---|---|
| Age at Diagnosis | ≤ 45 | 781 (16.2) | 4048 (83.8) | 4829 | <0.001 |
| 46–55 | 965 (16.9) | 4751 (83.1) | 5716 | ||
| 56–65 | 703 (15.8) | 3742 (84.2) | 4445 | ||
| 65 | 478 (10.8) | 3961 (89.2) | 4439 | ||
| Mean Age at Diagnosis (±SD)b | 53.7 (±12.56) | 55.8 (±14.20) | 55.5 (±13.98) | <0.001 | |
| Race | White | 2093 (13.9) | 13011 (86.1) | 15104 | <0.001 |
| Black | 698 (20.9) | 2635 (79.1) | 3333 | ||
| Other/Unknown | 136 (13.7) | 856 (86.3) | 992 | ||
| Hispanic | No | 2489 (14.9) | 14175 (85.1) | 16664 | 0.456 |
| Yes | 214 (16.0) | 1123 (84.0) | 1337 | ||
| Unknown | 224 (15.7) | 1204 (84.3) | 1428 | ||
| Charlson Comorbidity Score | 0 | 2609 (15.6) | 14123 (84.4) | 16732 | <0.001 |
| 1 | 258 (11.7) | 1955 (88.3) | 2213 | ||
| 2+ | 60 (12.4) | 424 (87.6) | 484 | ||
| Educationc | 21% or more | 546 (15.6) | 2943 (84.4) | 3489 | 0.155 |
| 13% - 20.9% | 750 (15.4) | 4117 (84.6) | 4867 | ||
| 7% - 12.9% | 903 (15.1) | 5063 (84.9) | 5966 | ||
| Less than 7% | 662 (14.0) | 4059 (86.0) | 4721 | ||
| Missing | 66 (17.1) | 320 (82.9) | 386 | ||
| Income | Less than $38,000 | 570 (16.1) | 2965 (83.9) | 3535 | 0.201 |
| $38,000 - $47,999 | 619 (14.4) | 3691 (85.6) | 4310 | ||
| $48,000 - $62,999 | 755 (15.0) | 4291 (85.0) | 5046 | ||
| $63,000 + | 916 (14.9) | 5226 (85.1) | 6142 | ||
| Missing | 67 (16.9) | 329 (83.1) | 396 | ||
| Insurance Status | Medicaid | 374 (17.5) | 1768 (82.5) | 2142 | <0.001 |
| Medicare | 534 (11.2) | 4229 (88.8) | 4763 | ||
| Not Insured | 133 (17.2) | 642 (82.8) | 775 | ||
| Other Government | 35 (16.1) | 182 (83.9) | 217 | ||
| Private Insurance | 1785 (15.9) | 9422 (84.1) | 11207 | ||
| Unknown | 66 (20.3) | 259 (79.7) | 325 | ||
| Urban settingd | Large metropolitan | 1656 (16.0) | 8708 (84.0) | 10364 | <0.001 |
| Small metropolitan | 784 (14.1) | 4789 (85.9) | 5573 | ||
| Suburban | 255 (14.3) | 1530 (85.7) | 1785 | ||
| Rural | 118 (11.8) | 879 (88.2) | 997 | ||
| Unknown | 114 (16.1) | 596 (83.9) | 710 | ||
| Distance to reporting facilitye | ≤10 | 1639 (15.5) | 8907 (84.5) | 10546 | 0.01 |
| 11 – 20 | 626 (14.4) | 3727 (85.6) | 4353 | ||
| 21 – 50 | 447 (15.3) | 2468 (84.7) | 2915 | ||
| >50 | 150 (12.1) | 1087 (87.9) | 1237 | ||
| Unknown | 65 (17.2) | 313 (82.8) | 378 | ||
| Geographic locationf | New England | 188 (18.8) | 810 (81.2) | 998 | <0.001 |
| Middle Atlantic | 396 (16.3) | 2037 (83.7) | 2433 | ||
| South Atlantic | 755 (15.9) | 3979 (84.1) | 4734 | ||
| East North Central | 533 (14.9) | 3050 (85.1) | 3583 | ||
| East South Central | 143 (11.5) | 1100 (88.5) | 1243 | ||
| West North Central | 157 (11.6) | 1195 (88.4) | 1352 | ||
| West South Central | 221 (14.2) | 1336 (85.8) | 1557 | ||
| Mountain | 120 (11.9) | 887 (88.1) | 1007 | ||
| Pacific | 414 (16.4) | 2108 (83.6) | 2522 | ||
| Facility Typeg | Community Cancer Program | ** | 1790 (84.6) | 2117 | <0.001 |
| Comprehensive Community Cancer Program | 1557 (14.0) | 9598 (86.0) | 11155 | ||
| Academic/Research Program | 1038 (16.9) | 5088 (83.1) | 6126 | ||
| Other/Missing | ** | 26 (83.9) | ** | ||
| Year of Diagnosis | 2004 | 248 (17.5) | 1166 (82.5) | 1414 | 0.001 |
| 2005 | 265 (16.7) | 1321 (83.3) | 1586 | ||
| 2006 | 292 (17.2) | 1410 (82.8) | 1702 | ||
| 2007 | 303 (14.9) | 1731 (85.1) | 2034 | ||
| 2008 | 404 (14.0) | 2488 (86.0) | 2892 | ||
| 2009 | 461 (14.9) | 2636 (85.1) | 3097 | ||
| 2010 | 447 (13.5) | 2876 (86.5) | 3323 | ||
| 2011 | 507 (15.0) | 2874 (85.0) | 3381 | ||
| Cancer Sequenceh | 1st | 2761 (15.6 | 14967 (84.4) | 17728 | <0.001 |
| 2+ | 166 (9.8)1 | 1535 (90.2) | 1701 | ||
| Tumor Size | 1 – 7 cm | 2186 (17.6) | 10221 (82.4) | 12407 | <0.001 |
| 7.1 – 10 cm | 609 (11.0) | 4925 (89.0) | 5534 | ||
| >10cm | 132 (8.9) | 1356(91.1) | 1488 | ||
| Mean Tumor Size (±SD)b | 74.1 (±74.25) | 78.8 (±71.16) | 78.1 (±71.65) | <0.001 | |
| No. of Nodes examined | 1 – 5 | 1318 (28.7) | 3274(71.3) | 4592 | <0.001 |
| 6 – 10 | 504 (13.2) | 3313 (86.8) | 3817 | ||
| 11 – 15 | 490 (10.7) | 4094 (89.3) | 4584 | ||
| 16 – 20 | 330 (9.9) | 3011 (90.1) | 3341 | ||
| >20 | 285 (9.2) | 2810 (90.8) | 3095 | ||
| Mean No. of Nodes Examined (±SD)b | 9.2 (±7.94) | 13.2 (±8.33) | 12.6 (±8.39) | <0.001 | |
| No. of Nodes Positive | 0 | 1524 (24.3) | 4748 (75.7) | 6272 | <0.001 |
| 1 – 3 | 919 (14.5) | 5401 (85.5) | 6320 | ||
| 4 – 6 | 212 (8.5) | 2291 (91.5) | 2503 | ||
| 7 – 9 | 112 (7.6) | 1371 (92.4) | 1483 | ||
| ≥10 | 160 (5.6) | 2691 (94.4) | 2851 | ||
| Mean No. of Nodes positive (±SD)b | 1.9 (±3.93) | 4.5 (±6.06) | 4.1 (±5.86) | <0.001 | |
| Grade | 1 | 162 (10.3) | 1410 (89.7) | 1572 | <0.001 |
| 2 | 795 (11.9) | 5875 (88.1) | 6670 | ||
| 3 | 1719 (17.7) | 7971 (82.3) | 9690 | ||
| Undifferentiated | 24 (16.3) | 123 (83.7) | 147 | ||
| Unknown | 227 (16.8) | 1123 (83.2) | 1350 | ||
| Histology | Ductal | 2449 (16.5) | 12359 (83.5) | 14808 | <0.001 |
| Lobular | 306 (8.1) | 3466 (91.9) | 3772 | ||
| Other | 172 (20.3) | 677 (79.7) | 849 | ||
| Radiation | Administered | 2545 (18.8) | 10976 (81.2) | 13521 | <0.001 |
| Not administered | 382 (6.5) | 5526 (93.5) | 5908 | ||
| Chemotherapy | Neoadjuvant | 1934 (19.8) | 7842 (80.2) | 9776 | <0.001 |
| Adjuvant | 664 (10.1) | 5914 (89.9) | 6578 | ||
| None | 316 (10.7) | 2641 (89.3) | 2957 | ||
| Unknown | 13 (11.0) | 105 (89.0) | 118 |
Abbreviations: SD- standard deviation
Chi-square test (categorical variables) or Wilcoxon rank sum test (continuous variables)
Cells have been censored in accordance with NCDB privacy requirements to do so for any cell <11 or for any cell that makes those cells calculable.
Numbers shown as number (row %) unless otherwise indicated.
Age and size analyses are shown here as continuous variables to illustrate cohort compositions.
Education represents the percentage of individuals within a ZIP code from census data having <12 years of education.
Setting definitions: Large metropolitan indicates counties of metropolitan areas of >1,000,000; Small metropolitan, counties in metropolitan areas of <250,000 to 1,000,000; Suburban, urban population of >20,000 adjacent to a metropolitan area or 2500 to 19,999 adjacent to a metropolitan area; rural, completely rural or <2500 or >20,000 urban population nonadjacent to a metropolitan area.
Miles between patient’s residence and the hospital that reported the case
Region groupings: New England (CT, MA, ME, NH, RI, VT), Middle Atlantic (NJ, NY, PA), South Atlantic (DC, DE, FL, GA, MD, NC, SC, VA, WV), East North Central (IL, IN, MI, OH, WI), East South Central (AL, KY, MS, TN), West North Central (IA, KS, MN, MO, ND, NE, SD), West South Central (AR, LA, OK, TX), Mountain (AZ, CO, ID, MT, NM, NV, UT, WY), Pacific (AK, CA, HI, OR, WA).
Community Cancer program: >100 but <500 newly diagnosed cancer cases each year; Comprehensive community cancer program: 500 or more new cases for three consecutive years; Academic/Research program: participates in postgraduate medical education in at least four program areas, and >500 newly diagnosed cancer cases each year.
The number of the cancer that the breast cancer represents, among cancers of any type, if they had >1 cancer of any type during their lifetime.