Table 2:
Predictors of BCT (cT3 patients)
| OR | 95% CI | p-value | Overall Significance | ||
|---|---|---|---|---|---|
| Age | <0.001 | ||||
| ≤45 | 0.928 | 0.760 | 1.133 | 0.462 | |
| 46 – 55 | 1.145 | 0.954 | 1.376 | 0.147 | |
| 56 – 65 | 1.211 | 1.014 | 1.447 | 0.035 | |
| >65 | Referent | ||||
| Race | <0.001 | ||||
| White | Referent | ||||
| Black | 1.471 | 1.310 | 1.652 | <0.001 | |
| Unknown | 0.766 | 0.616 | 0.953 | 0.017 | |
| Hispanic | 0.297 | ||||
| No | Referent | ||||
| Yes | 1.077 | 0.897 | 1.293 | 0.426 | |
| Unknown | 1.140 | 0.952 | 1.365 | 0.155 | |
| Charlson Comorbidity Score | 0.051 | ||||
| 0 | Referent | ||||
| 1 | 0.836 | 0.716 | 0.975 | 0.022 | |
| 2 | 1.049 | 0.770 | 1.428 | 0.764 | |
| Insurance | 0.060 | ||||
| Private Insurance | Referent | ||||
| Medicaid | 1.086 | 0.944 | 1.250 | 0.249 | |
| Medicare | 0.948 | 0.798 | 1.126 | 0.544 | |
| Not Insured | 1.023 | 0.813 | 1.288 | 0.844 | |
| Other | 1.052 | 0.694 | 1.593 | 0.813 | |
| Unknown | 1.762 | 1.272 | 2.440 | 0.001 | |
| Educationa | 0.318 | ||||
| 21% or more | Referent | ||||
| 13% - 20.9% | 1.139 | 0.983 | 1.319 | 0.084 | |
| 7% - 12.9% | 1.153 | 0.972 | 1.369 | 0.103 | |
| Less than 7% | 1.063 | 0.872 | 1.296 | 0.547 | |
| Missing | 1.912 | 0.055 | 66.780 | 0.721 | |
| Income | 0.755 | ||||
| < $38,000 | Referent | ||||
| $38,000 - $47,999 | 0.907 | 0.783 | 1.050 | 0.190 | |
| $48,000 - $62,999 | 0.921 | 0.786 | 1.078 | 0.306 | |
| $63,000 + | 0.896 | 0.740 | 1.084 | 0.259 | |
| Missing | 0.706 | 0.026 | 19.254 | 0.836 | |
| Urban settingb | 0.330 | ||||
| Large Metropolitan | Referent | ||||
| Small metropolitan | 0.912 | 0.805 | 1.033 | 0.148 | |
| Suburban | 0.832 | 0.677 | 1.022 | 0.079 | |
| Rural | 0.991 | 0.736 | 1.335 | 0.955 | |
| Unknown | 0.964 | 0.719 | 1.291 | 0.804 | |
| Distance to reporting facility (miles)c | 0.236 | ||||
| ≤10 | Referent | ||||
| 11 – 20 | 0.944 | 0.848 | 1.050 | 0.288 | |
| 21 – 50 | 1.108 | 0.964 | 1.274 | 0.148 | |
| >50 | 0.952 | 0.750 | 1.209 | 0.688 | |
| Unknown | 0.857 | 0.226 | 3.242 | 0.820 | |
| Geographic locationd | <0.001 | ||||
| New England | Referent | ||||
| Middle Atlantic | 0.816 | 0.639 | 1.043 | 0.105 | |
| South Atlantic | 0.778 | 0.619 | 0.978 | 0.032 | |
| East North Central | 0.728 | 0.566 | 0.937 | 0.008 | |
| East South Central | 0.558 | 0.413 | 0.755 | 0.000 | |
| West North Central | 0.539 | 0.399 | 0.729 | <0.001 | |
| West South Central | 0.757 | 0.561 | 1.023 | 0.070 | |
| Mountain | 0.641 | 0.4773 | 0.869 | 0.004 | |
| Pacific | 0.925 | 0.724 | 1.183 | 0.536 | |
| Facility Typee | 0.005 | ||||
| Community Program | Referent | ||||
| Comprehensive Community | 0.797 | 0.676 | 0.939 | 0.007 | |
| Academic/Research | 0.963 | 0.801 | 1.158 | 0.687 | |
| Other/Missing | 0.911 | 0.704 | 1.179 | 0.478 | |
| Year of diagnosis | 0.951 | 0.932 | 0.970 | <0.001 | <0.001 |
| Cancer Sequencef | <0.001 | ||||
| First | Referent | ||||
| 2+ | 0.715 | 0.600 | 0.852 | 0.001 | |
| Tumor size | <0.001 | ||||
| 5.1 to 7 cm | Referent | ||||
| 7.1 to 10 cm | 0.576 | 0.521 | 0.637 | <0.001 | |
| >10 cm | 0.457 | 0.367 | 0.568 | <0.001 | |
| No. nodes examined | 0.948 | 0.941 | 0.975 | <0.001 | <0.001 |
| No. nodes positive | 0.928 | 0.914 | 0.943 | <0.001 | <0.001 |
| Grade | <0.001 | ||||
| 1 | Referent | ||||
| 2 | 1.123 | 0.930 | 1.356 | 0.252 | |
| 3 | 1.542 | 1.275 | 1.866 | <0.001 | |
| Undifferentiated | 1.250 | 0.790 | 1.979 | 0.355 | |
| Unknown | 1.416 | 1.114 | 1.801 | 0.005 | |
| Histology | <0.001 | ||||
| Ductal | Referent | ||||
| Lobular | 0.604 | 0.524 | 0.696 | <0.001 | |
| Other | 1.264 | 1.056 | 1.513 | 0.011 | |
| Chemotherapy | <0.001 | ||||
| Adjuvant | Referent | ||||
| Neoadjuvant | 1.687 | 1.499 | 1.898 | <0.001 | |
| None | 1.533 | 1.283 | 1.832 | <0.001 | |
| Unknown | 1.841 | 0.969 | 3.499 | 0.062 | |
| Radiotherapy | <0.001 | ||||
| Administered | Referent | ||||
| Not administered | 0.259 | 0.228 | 0.294 | <0.001 | |
Abbreviations: BCT, breast conservation therapy; cT3, clinical T3 patients
Education represents the percentage of individuals within a ZIP code from census data having <12 years of education.
Setting definitions: Large metropolitan indicates counties of metropolitan areas of >1,000,000; Small metropolitan, counties in metropolitan areas of <250,000 to 1,000,000; Suburban, urban population of >20,000 adjacent to a metropolitan area or 2500 to 19,999 adjacent to a metropolitan area; rural, completely rural or <2500 or >20,000 urban population nonadjacent to a metropolitan area.
Miles between patient’s residence and the hospital that reported the case
Region groupings: New England (CT, MA, ME, NH, RI, VT), Middle Atlantic (NJ, NY, PA), South Atlantic (DC, DE, FL, GA, MD, NC, SC, VA, WV), East North Central (IL, IN, MI, OH, WI), East South Central (AL, KY, MS, TN), West North Central (IA, KS, MN, MO, ND, NE, SD), West South Central (AR, LA, OK, TX), Mountain (AZ, CO, ID, MT, NM, NV, UT, WY), Pacific (AK, CA, HI, OR, WA).
Community Cancer program: >100 but <500 newly diagnosed cancer cases each year; Comprehensive community cancer program: 500 or more new cases for three consecutive years; Academic/Research program: participates in postgraduate medical education in at least four program areas, and >500 newly diagnosed cancer cases each year.
The number of the cancer that the breast cancer represents, among cancers of any type, if they had >1 cancer of any type during their lifetime.