Table 3.
Comparison of Severe ROP Status
| No Severe ROP N =1510 |
Severe ROP N= 126 |
p-Value | |
|---|---|---|---|
| Gestational age at birth, mean ± SD, weeks | 28.3 ± 2.8 | 25 ± 1.6 | <0.001 |
| Birth weight, mean ± SD, grams | 1207 ± 432 | 754 ± 194 | <0.001 |
| Birth weight percentile, mean ± SD | 46 ± 28 | 44 ± 26 | 0.301 |
| Intrauterine growth restriction, n (%) | 159 (11) | 13 (10) | 0.94 |
| Male sex, n (%) | 795 (53) | 71 (56) | 0.424 |
| African-American race, n (%) | 671 (44) | 55 (44) | 0.864 |
| Antenatal steroids, n (%) | 1249 (83) | 104 (83) | .960 |
| Apgar 5 min, mean ± SD | 6.2 ± 2.2 | 4.9 ± 2.4 | <0.001 |
| Received inotropes, n (%) | 447 (30) | 93 (74) | <0.001 |
| Chorioamnionitisa, n (%) | 375 (25) | 44 (34) | 0.013 |
| PDA requiring surgery, n (%) | 109 (7) | 47 (37) | <0.001 |
| NECb, n (%) | 99 (7) | 12 (10) | 0.203 |
| BPDc, n (%) | 409 (27) | 103 (82) | <0.001 |
| Postnatal steroids, n (%) | 142 (9) | 78 (62) | <0.001 |
| Culture positive sepsis, n (%) | 104 (7) | 23 (18) | <0.001 |
| Died prior to discharge, n (%) | 214 (14) | 7 (6) | 0.007 |
| Early Transfusion, n (%) | 487 (32) | 115 (91) | <0.001 |
| Late Transfusion, n (%) | 241 (16) | 8 (6) | 0.003 |
| Initial Hgb, mean ± SD | 14.3 ± 3.0 | 13.0 ± 2.8 | <0.001 |
| Number of transfusion, median (interquartile range) | 0 (3) | 8 (6) | <0.001 |
Footnotes:
a
Based on histologic examination of the placenta,
b
Defined as Bell Stage 2a or greater,
c
Defined as need for supplemental oxygen at 36 weeks PMA.