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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Pharmacol Res. 2019 Jan 2;141:331–342. doi: 10.1016/j.phrs.2019.01.002

Fig. 8. Proposed mechanism of AEA-mediated down-regulation of BCRP and syncytialization-related genes.

Fig. 8.

AEA binds to and activates the CB2 receptor, which in turn inhibits adenylyl cyclase. The corresponding decrease in cAMP production reduces basal protein kinase A (PKA) activation and, therefore, CREB phosphorylation. The DNA sequence for BCRP, along with genes involved in trophoblast syncytialization, contain a cAMP response element (BP −504 to −403) to which p-CREB would normally bind. Decreased p-CREB signaling would therefore reduce BCRP transcription and efflux activity.