. Author manuscript; available in PMC: 2020 Mar 1.

Published in final edited form as: Pharmacol Res. 2019 Jan 2;141:331–342. doi: 10.1016/j.phrs.2019.01.002

Table 1.

Effect of AEA on cell viability in the presence of BCRP substrates and environmental contaminants.

	LC₅₀ values (μM)
	Control	Ko143^a	AEA

MTX^b	10.7 ± 1.1	3.1 ± 1.8^*	3.2 ± 1.3^*
ZLN	182.9 ± 3.7	84.8 ± 19.3^*	73.9 ± 33.3^*
α-ZRN	77.4 ± 6.4	36.0 ± 10.1^*	27.4 ± 9.1^*
PFOA	672.9 ± 58.2	450.0 ± 163.9	326.3 ± 47.3
PFOS	724.7 ± 56.8	438.3 ± 87.7^*	277.5 ± 74.6^*

LC₅₀ values are presented as the mean of three experiments +/− SEM.

Statistically significant differences (p < 0.05) compared to control cells as determined by one-way ANOVA with Newman-Keuis post-test.

BeWo cells were incubated in the presence of Ko143 (1 μM), AEA (10 μM), or vehicle (rows) and various concentrations of known or potential BCRP substrates (columns)

Abbreviations: MTX, mitoxantrone; ZLN, zearalenone; α-ZRN, α-zearalanol; PFOA, perfluorooctanoic acid; PFOS, perfluorooctanesulfonic acid