Table 3.

Adjusted associations between demographic and clinical variables, relative mtDNA copy number, and neurocognitive impairment by global deficit score (GDS ≥0.5).

Variable	Coefficient (±2x SE)	P value
Peripheral blood mtDNA copy number	0.48 ± 0.23	<0.0001
Platelet / WBC ratio	−0.01 ± 0.01	0.02
Age (per 10 years)	0.04 ± .09	0.68
Female sex	0.23 ± 0.34	0.18
Genetic PC1	−1.23 ± 5.46	0.65
Genetic PC2	10.63 ± 5.40	<0.0001
Genetic PC3	1.39 ± 5.25	0.60
Estimated duration of HIV (per year)	0.01 ± 0.02	0.56
Contributing comorbidity	0.67 ± 0.28	<0.0001
Nadir CD4+ T-cell count (per 100 cells)	0.10 ± 0.08	0.02
Plasma HIV RNA ≤50 copies/mL	0.09 ± 0.28	0.52