Table 3.
The effects of Salvianolic acids on cancer.
| Type of cancer | Compounds | Cells/Tissues | Effects | Reference |
|---|---|---|---|---|
| Breast cancer | Sal A | MCF-7/PTX cells | ABC transporter Drug resistance PI3K/Akt signaling Transgelin 2 Cell migration and invasion | Cai et al., 2014; Zheng et al., 2015 |
| MCF-7 cells | Cell proliferation Cell apoptosis Multidrug resistance | Wang et al., 2015 | ||
| Mitochondrial membrane potential | ||||
| MCF7cells MDA-MB-231 cells | Multidrug resistance Drug delivery system | Ding et al., 2016 | ||
| Head and neck squamous cell carcinoma | Sal B | HN13 cells HN30 cells | Cell apoptosis Cell cycle | Li H. et al., 2016 |
| JHU-022 cells JHU-013 cells | Cell growth Tumor volumes | Hao et al., 2009 | ||
| JHU-06 cells JHU-011 cells JHU-013 cells JHU-022 cells | Cell apoptosis Tumor volumes | Zhao et al., 2010 | ||
| Lung cancer | Sal A | W1-38 cells A549 cells | P46 (JNK/SAPK) expression | Li et al., 2002 |
| Sal B | A549 cells | COX-2 activity Cell growth | Tao et al., 2014 | |
| Salvianolic acids | A549 cells | PTEN/PI3K/AKT pathway EMT | Yang et al., 2017 | |
| Sal A | A549 cells | MDR1 microRNA | Chen F. Y. et al., 2016 | |
| Squamous cell carcinoma | Sal B | Hamsters tissues | Angiogenesis Hypoxia-inducible factor 1alpha Vascular endothelium growth factor protein | Zhou et al., 2006 |
| Oral squamous cell carcinoma | Sal B | CAL27 cells SCC4 cells | HIF-1α, TNFα MMP9 THBS2 anti-angiogenic | Yang et al., 2011 |
| Sal A | SCC-9 cells SCC-25 cells | MMP-2 c-Raf/MEK/ERK Invasion and migration of OSCC | Fang et al., 2018 | |
| Retinoblastoma | Sal B | HXO-RB44 cells | Cell apoptosis Cell cycle Cell growth | Liu, 2012 |
| Ovarian cancer | Sal B | SKOV3 cells | Cell apoptosis livin Cell growth | Yan, 2016 |
| Melanoma | Danshensu | B16F10 cells | Tumor angiogenesis Tumor invasion | Zhang et al., 2010 |
| Colorectal cancer | Sal B | LoVo cells HCT-116 cells | CD44, SOX2 ABCG2 multidrug resistance | Guo et al., 2018 |
| HCT116 cells HT29 cells | AKT/mTOR pathway Cell autophagy | Jing et al., 2016 | ||
| Liver cancer | Sal B | HCC cells | Cell apoptosis Cell autophagy AKT/mTOR pathway | Gong et al., 2016 |
| Salvianolic acids | HepG2 | Cell invasion TGF-β/ Smad | Liu et al., 2010 | |
| Sal A | H22 cells | Tumor growth | Li et al., 2002 | |