Table 1.
VRE-BSI using 447 E. faecium and 613 E. faecalis comparing LZD and TZD in terms of tissue burden (CFUcount) [log CFU/g ±SD] at EOT on day 4.
| Strains | Antibiotics | Kidney | Spleen | Lung | Blood | |
|---|---|---|---|---|---|---|
| 447S (no. of mice) | Treatment (7) | TZD | 6.06 ± 0.64 | 2.58 ± 0.60 | 2.93 ± 0.66 | 0 |
| LZD | 5.43 ± 0.25* | 2.97 ± 0.25 | 3.13 ± 0.47 | 0 | ||
| Relapse (7) | TZD | 7.07 ± 1.11 | 3.05 ± 0.99 | 3.73 ± 0.95 | 1.28 ± 1.19 | |
| LZD | 5.28 ± 0.46* | 3.15 ± 0.84 | 3.44 ± 0.64 | 0.94 ± 0.69 | ||
| 613S (no. of mice) | Treatment (7) | TZD | 7.82 ± 0.38 | 4.72 ± 0.81 | 5.39 ± 0.36 | 2.11 ± 0.92 |
| LZD | 5.97 ± 1.05* | 4.00 ± 0.38* | 3.80 ± 0.31* | 0.56 ± 0.72* | ||
| Relapse (7) | TZD | 7.49 ± 0.56 | 4.33 ± 1.23 | 4.43 ± 1.14 | 2.17 ± 0.84 | |
| LZD | 7.56 ± 0.90 | 4.29 ± 0.86 | 4.29 ± 0.73 | 2.26 ± 0.93 |
*
P < 0.05 TZD vs. LZD.