Figure 2.

FGF21 decreases hypoxia stress-induced apoptosis in CMECs. (A) Representative images of fluorescent TUNEL staining in CMECs under the condition of normoxia and hypoxia (1% O₂) with FGF21 treatment (50 nM) or vehicle for 8 h. **p < 0.01 vs. Veh. N = 8. (B) Representative images of immunoblotting assay of caspase-3 and cleaved caspase-3 in CMECs challenged by hypoxia (1% O₂) with FGF21 treatment (50 nM) or vehicle for 8 h. **p < 0.01 N = 8. Veh, vehicle. For N = 8, experiments were conducted in eight different wells of cultured cells.