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. 2019 Feb 20;10:101. doi: 10.3389/fphar.2019.00101

Figure 5.

Figure 5

FGF21 limits hypoxia-induced inflammation in CMECs. (A) Quantitative analysis of cyclooxygenase-2 (COX-2) activity in CMECs under the condition of normoxia and hypoxia (1% O2) with FGF21 treatment (50 nM) or vehicle for 8 h. **p < 0.01 vs. Veh. N = 8. (B) Quantitative analysis of NF-κB-p65 transcriptional activity in CMECs challenged by hypoxia (1% O2) with FGF21 treatment (50 nM) or vehicle for 8 h. **p < 0.01 vs. Veh. N = 8. Veh, vehicle. For N = 8, experiments were conducted in eight different wells of cultured cells.