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. 2019 Feb 20;10:101. doi: 10.3389/fphar.2019.00101

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Copyright © 2019 Wang, Jiang, Zhang, Wang, Xie, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of HSP72 abolishes the protection of FGF21 against hypoxia in CMECs. (A,B) The effects of siRNA targeting to HSP72 on the mRNA (A) and protein (B) expression of HSP72 in CMECs. *p < 0.05. N = 6. Actin was used as a loading control. (C,E) The cell viability (C), LDH release (D), and ROS (E) of normal or HSP72-knockdown CMECs under the condition of normoxia and hypoxia (1% O₂) with FGF21 treatment (50 nM) for 8 h. *p < 0.05. N = 8. Veh, vehicle. For N = 6 or 8, experiments were conducted in eight different wells of cultured cells.