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. 2019 Feb 20;10:101. doi: 10.3389/fendo.2019.00101

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Copyright © 2019 Zhong and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription factors involve in differentiation of pancreatic cell lineages. In the diagrammatic sketch for pancreatic cell differentiation, the process of differentiation from multipotent pancreatic progenitors to α or β cells is presented; and the combination of key TFs determining the specialization of endocrine and exocrine pancreatic cell lineages is displayed. The figure was reproduced with permission from Elsevier and Copyright Clearance Center. This figure was adapted from Hang and Stein (67).