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. 2019 Feb 20;10:101. doi: 10.3389/fendo.2019.00101

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Copyright © 2019 Zhong and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mouse model for the study of β cell regeneration. The targeting to pancreatic β cells is relayed on the driving of insulin promoter, and conditional ablation (or labeling) is dependent on the induction under Dox, AP20187 or Tam administration in specific transgenic strains. (A) Dox-induced DT-dependent specific ablation of β cells; (B) Caspase-FKBP-induced apoptosis of pancreatic β cells conditionally activated by AP2018; and (C) Tam-induced lineage tracing of pancreatic β cells based on CreERT: Rosa26-LoxP-Reporter transgenic strains.