Table 1.
Potential drugs for increasing pancreatic β cell replication.
| Inhibitor | Rodent model | Human islet | Pathway | References |
|---|---|---|---|---|
| Harmine | Px | h-islet-NSG | DYRK1A | (61) |
| 5-iodotubercidin | ND | h-islet-NSG | DYRK1A | (62) |
| Osteoprotegrin | STZ-mice | β cells in vitro | RANKL, GSK3 | (63) |
| Denosumab | ND | h-islet-NSG | RANKL | (63) |
| Aminopyrazine (GNF7156, GNF4877) | DTA-induced diabetic mice | h-islet-NSG | DYRK1A, GSK3B | (64) |
| Serpin B1 (sivelestat, W311616A) | C57Bl/6 | h-islet-NSG | protease | (49) |
| shRNA targeting to p21 and p18 | ND | Human islets in vitro | p18, p21 | (65) |
ND, not determined; h-islet-NSG, human islet graphed into NSG mice.