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. 2019 Feb 20;13:133. doi: 10.3389/fnins.2019.00133

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Copyright © 2019 Xu, Jiao, Tang, Zhang, Salvi and Teng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Whole-brain voxel-wise functional connectivity patterns of the insula subdivisions (p < 0.001, false discovery rate corrected). (A) Comparing with Controls, functional connectivity was significantly decreased between left vAI and bilateral thalamus and right precentral gyrus in SNHL subjects. (B) The left dAI showed significant decreased functional connectivity with right thalamus, putamen, mid-cingulate cortex, precentral gyrus, postcentral gyrus, and DLPFC. (C) The right dAI showed decreased connectivity with right rolandic operculum. (D) The right PI showed weakened connections with right thalamus and precentral gyrus. SNHL, sensorineural hearing loss; vAI, ventral anterior insula; dAI, dorsal anterior insula; PI, posterior insula; DLPFC, dorsolateral prefrontal cortex; L, left; R, right.