Table 2.
Cell viability (IC50), hemolytic activity and hydrophobicity of second-generation peptidomimetics.
| Compound | IC50 (μg/mL); confidence intervals are stated in brackets |
HD10 (μM)∗ | % B∗∗ | |||
|---|---|---|---|---|---|---|
| HepG2 | NIH 3T3 | |||||
| LBP-2 | 63.1 | (59.7–67.0) | 181.0 | (153.0–217.0) | >300 | 37.8 |
| LBP-3 | 24.3 | (20.8– 8.3) | 65.3 | (60.4–70.6) | <4.7 (81%) | 43.8 |
| LBP-4 | 33.7 | (31.2–37.9) | 104.0 | (95.4–113.0) | <4.7 (100%) | 49.3 |
∗HD10 designates the concentration of peptidomimetic that results in hemolysis of 10% of human red blood cells; values are also stated in brackets as percent of hemolysis at 4.7 μM. ∗∗Hydrophobicity is indicated by the percentage of acetonitrile (%B) at the peak elution time on analytical reversed-phase HPLC.