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. 2019 Feb 26;2:79. doi: 10.1038/s42003-019-0327-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — PET/CT imaging and biodistribution of ⁸⁶Y-NM600 in mice bearing T-cell NHLs. Representative maximum intensity projections (MIP) of PET/CT images showing prominent and persistent tumor uptake in mice bearing EL4 (a) or Hut-102 (b) injected 9.25 MBq ⁸⁶Y-NM600. Free ⁸⁶Y (c) injection in EL4 bearing mice showed marked uptake in bone but lower accumulation in EL4 tumors. Yellow arrowheads point to the tumor. ROI quantitative analysis of ⁸⁶Y-NM600 (d, e) and free ⁸⁶Y (f) biodistribution in EL4 and Hut-102 tumor-bearing mice. g Ex vivo biodistribution was performed after the final imaging time point 68 h p.i. Numerical data are presented as %IA/g (mean ± SD)