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. 2019 Feb 26;9:2814. doi: 10.1038/s41598-019-39116-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of H89 on phosphoproteomes of PKA-intact and PKA-null mpkCCD cells. Volcano plots show global effects of H89 on phosphoproteome of PKA-intact cells (a) and PKA-null cells (b). Each point represents a phosphosite, x-axis denotes estimated effect size of H89 (β_H89; positive and negative values mean H89 treatment increases and decreases phosphorylation, respectively). Y-axis represents negative of log₁₀ P value for β_H89. Significantly changed phosphosites, determined by P value < 0.05 and |β_H89| > 0.15, are colored with red. (c) Distribution of total protein abundance ratios for PKA-intact and PKA-null cells show little or no change in response to H89 treatment. (d) Correlation between β_H89 in PKA-intact and PKA-null cells is observed (Pearson’s correlation R = 0.53).