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. 2019 Feb 26;9:2840. doi: 10.1038/s41598-019-39090-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative SC and IC maps. (A) SC level maps obtained during FUS treatment at two different time points (1 s and 60 s). (B) SCD map acquired by integrating the SC level for reach pixel through the total FUS treatment time. (C) Representative SC level-time curve for the pixel identified by the cross in B. (D–F) Corresponding IC level maps, ICD map, and IC level-time curve.