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. 2019 Feb 26;9:2840. doi: 10.1038/s41598-019-39090-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The ex vivo mouse brains were sliced coronally into 2-mm slices, and the slice containing the targeted brainstem was cut into two halves for quantifying the radioactivity in each half (illustrated by the rectangle boxes). The SCD was also averaged within each half of the brain for identifying the correlation between SCD and radioactivity. (B) The radioactivity of ⁶⁴Cu-AuNCs quantified using gamma counting and (C) the gold concentration of ⁶⁴Cu-AuNCs quantified using ICP-MS in the FUS-treated halves and contralateral non-treated halves were well correlated with the corresponding spatial-averaged SCD within the same brain regions using the segmented linear regression (R² = 0.62 for gamma counting and R² = 0.53 for ICP-MS).