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. 2019 Feb 26;9:2779. doi: 10.1038/s41598-019-39174-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Age at greatest vulnerability to increased apoptosis induced by ISO in the developing mouse brain is region-specific. Mouse pups were exposed to 1.5% ISO or AIR only for 3 h on P3, P5, or P7, and processed for AC3+ IHC beginning 6 h after initiation of exposure. Representative AC3+ IHC images of mouse pup brain at the ages at which the greatest increase in apoptotic neurodegenerative response induced by ISO above typical developmental levels (AIR) was observed. Thalamus, P3; Hippocampus, P5; Striatum, P5; Cortex; P5. Scale bar is 50 µm.