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. 2019 Feb 26;9:2799. doi: 10.1038/s41598-019-38730-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rescue of decreased cell number and hypertrophy of Purkinje cells in PC-mTOR Tg mice by administration of rapamycin. (a) Morphology of Purkinje cells stained with calbindin antibody. Intraperitoneal administration of rapamycin to PC-mTOR Tg mice at 3–6 weeks of age dramatically suppressed both hypertrophy of cell body and reduction of Purkinje cell density. Scale bars, 50 μm. (b,c) Quantification of density and soma size of Purkinje cells from the control, PC-mTOR Tg and Tg mice that received rapamycin injection. These results indicate that Purkinje cell phenotypes observed in PC-mTOR Tg mice are attributable to activation of mTORC1 signaling. *p < 0.001 by one-way ANOVA with Tukey; control, n = 15 slices from 3 mice; PC-mTOR Tg, n = 9 slices from 2 mice; PC-mTOR Tg + rapamycin, n = 10 slices from 2 mice (b); control, n = 188 cells from 3 mice; PC-mTOR Tg, n = 71 cells from 2 mice; PC-mTOR Tg + rapamycin, n = 194 cells from 2 mice (c). n.s., not significant.