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. 2019 Feb 26;9:2799. doi: 10.1038/s41598-019-38730-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gait analysis and rotarod test of PC-mTOR Tg mice. (a,b) Footprint patterns of control and PC-mTOR Tg mice. In PC-mTOR Tg mice, distance between left and right hind paw traces was significantly wider than the control, indicative of the ataxic gait. Scale bars, 1 cm. *p < 0.001 by Student t-test; control, n = 6; PC-mTOR Tg, n = 5. (c) Rotarod test of 6-week-old mice. An accelerating rotarod was used to measure the motor coordination and motor learning of mice. Retention time on the rotating rod was significantly lower in PC-mTOR Tg mice (close circles) then the control (open circles) over the course of multiple training days. Administration of rapamycin to PC-mTOR Tg mice drastically rescued the motor discoordination (red circles) without any significant differences from control mice. Values are mean ± SEM of three consecutive trials. *p < 0.001 and **p < 0.05 by two-way ANOVA with Tukey for both PC-mTOR Tg and PC-mTOR Tg + rapamycin compared to control; control, n = 5; PC-mTOR Tg, n = 6; PC-mTOR Tg + rapamycin, n = 5. n.s., not significant.