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. 2019 Feb 26;9:2811. doi: 10.1038/s41598-019-39569-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Temporal course of CMD-tryptophan (A), CMD-phenylalanine (B) and CMD-tyrosine (C); patients with a medical history of depression showed significantly lower levels of all 3 amino-acids compared to patients without depression. Patients with antidepressant intake 12 months after subarachnoid hemorrhage showed significantly lower levels of CMD-tryptophan compared to patients without. Statistical analysis was performed using a linear model in generalized estimating equations with amino-acid levels as dependent and depression groups as independent variable. All analyses were adjusted for Hunt & Hess-grade, age, modified-Fisher Score and probe location. DEP_no = patients with neither a medical history of depression nor antidepressant medication use 12 months after the subarachnoid hemorrhage; DEP_prior+ = patients with a medical history of depression; DEP_post+ = patients with no medical history of depression but with anti-depressant medication use 12 months after the subarachnoid hemorrhage; CMD = cerebral microdialysis; SAH = subarachnoid hemorrhage.