Table 4.
Comparison of neuromonitoring parameters between groups.
| Neuromonitoring parameter | DEPno (reference) | DEPprior+ | DEPpost+ | Deceased | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | OR | 95%CI | p-value | Median (IQR) | OR | 95%CI | p-value | Median (IQR) | OR | 95%CI | p-value | |
| CMD-Glucose (mmol/l) | 1,01 (0,68–1,63) | 1,46 (1,05–2,21) | 1,16 | 0,98–1,38 | 0,09 | 1,29 (0,85–2,05) | 1,12 | 0,93–1,35 | 0,24 | 0,94 (0,71–1,31) | 0,93 | 0,81–1,07 | 0,32 |
| CMD-Lactate (mmol/l) | 3,75 (2,61–5,78) | 2,93 (2,18–3,39) | 0,88 | 0,74–1,03 | 0,11 | 3,23 (2,48–4,20) | 0,94 | 0,82–1,08 | 0,39 | 5,75 (3,80–7,44) | 1,15 | 0,98–1,34 | 0,08 |
| CMD-Pyruvate (umol/l) | 138,8 (94,2–181,6) | 113,4 (80,2–136,5) | 0,9 | 0,77–1,05 | 0,17 | 99,9 (74,8–140,9) | 0,89 | 0,78–1,01 | 0,07 | 123,5 (90,2–153,6) | 0,93 | 0,84–1,04 | 0,21 |
| CMD-LPR | 28,6 (24,2–33,7) | 26,4 (23,3–29,9) | 0,97 | 0,90–1,04 | 0,36 | 29,7 (24,7–43,2) | 1,05 | 0,93–1,12 | 0,46 | 43,8 (34,4–53,0) | 1,23 | 1,10–1,34 | 0,001* |
| CMD-Glutamate (umol/l) | 13,8 (1,8–92,8) | 6,9 (3,2–16,8) | 0,84 | 0,44–1,60 | 0,6 | 3,1 (2,2–4,8) | 0,72 | 0,43–1,19 | 0,2 | 39,3 (5,2–87,8) | 2,25 | 1,01–5,04 | 0,05* |
| Metabolic distress (%) | 0 (0–8) | 0 (0–7) | 0,94 | 0,84–1,05 | 0,29 | 0 (0–72) | 1,17 | 0,87–1,58 | 0,29 | 62,5 (14–100) | 1,7 | 1,44–1,99 | <0,001* |
| Mitochondrial dysfunction (%) | 10 (0–83) | 0 (0–47) | 0,91 | 0,68–1,22 | 0,53 | 17 (0–70) | 1,01 | 0,73–1,40 | 0,96 | 90 (54–100) | 1,42 | 1,14–1,78 | 0,002* |
| Neuroglucopenia (%) | 11 (0–33) | 0 (0–17) | 0,96 | 0,67–1,38 | 0,84 | 0 (0–17) | 0,95 | 0,70–1,28 | 0,73 | 23 (6–31) | 1,18 | 0,96–1,45 | 0,11 |
| ICP crisis (%) | 0 (0–4) | 0 (0–4) | 0,98 | 0,93–1,03 | 0,44 | 0 (0–0) | 0,99 | 0,94–1,04 | 0,75 | 0 (0–39) | 1,85 | 1,16–2,97 | 0,01* |
| CPP (mmHg) | 79,2 (69,4–89,3) | 76,1 (69,9–83,8) | 1 | 0,95–1,05 | 0,88 | 76,0 (69,3–87,0) | 1 | 0,95–1,05 | 0,95 | 83,4 (66,5–79,8) | 0,97 | 0,93–1,01 | 0,15 |
Data are shown as n (%) or median (interquartile range). Odds ratios and p-values refer to the comparison of patients with a medical history of depression, patients with antidepressant drug use after 12 months or patients who died to patients with no medical history of depression and no antidepressant drug use after 12 months. An asterisk (*) signifies significant differences, which were only found in patients who died. DEPno = patients with neither a medical history of depression nor antidepressant medication use 12 months after the subarachnoid hemorrhage; DEPprior+ = patients with a medical history of depression; DEPpost+ = patients with no medical history of depression but with anti-depressant medication use 12 months after the subarachnoid hemorrhage; CMD = cerebral microdialysis; IQR = interquartile range; OR = odds ratio; 95% CI = 95% confidence interval; LPR = lactate-to-pyruate-ratio; ICP = intracranial pressure; CPP = cerebral perfusion pressure (mean arterial pressure minus intracranial pressure).