Table 1.
Description of high-risk CLL pedigrees
| Pedigree | Members | Generations | CLL | Sampled relatives | Heme malignancies | B-cell lymphoid malignancies | Solid tumors |
|---|---|---|---|---|---|---|---|
| 6204 | 57 | 6 | 4 | 3 | 1 | 1 | 9 |
| 6205 | 71 | 7 | 7 | 3 | 0 | 0 | 6 |
| 6207 | 285 | 9 | 26 | 4 | 3 | 3 | 31 |
| 6208 | 62 | 6 | 5 | 4 | 1 | 1 | 4 |
| 6210 | 40 | 5 | 4 | 3 | 0 | 0 | 4 |
| 6211 | 189 | 7 | 15 | 10 | 1 | 0 | 33 |
| 6213 | 20 | 3 | 2 | 1 | 1 | 0 | 4 |
| 6215 | 36 | 5 | 4 | 6 | 0 | 0 | 0 |
| 6217 | 17 | 3 | 3 | 8 | 1 | 1 | 3 |
| 6218 | 42 | 6 | 4 | 2 | 1 | 0 | 5 |
| 6222 | 12 | 3 | 4 | 1 | 1 | 0 | 2 |
| 6223 | 47 | 5 | 3 | 4 | 1 | 1 | 3 |
| 6224 | 21 | 4 | 3 | 2 | 0 | 0 | 3 |
| 6225 | 32 | 4 | 4 | 4 | 0 | 0 | 8 |
| 6226 | 85 | 6 | 7 | 10 | 0 | 0 | 10 |
| 6228 | 130 | 7 | 12 | 7 | 2 | 2 | 18 |
| 6229 | 120 | 6 | 11 | 2 | 2 | 1 | 19 |
| 6232 | 25 | 4 | 2 | 8 | 3 | 3 | 1 |
| 6233 | 247 | 7 | 24 | 14 | 8 | 6 | 26 |
| 6234 | 218 | 6 | 19 | 6 | 6 | 4 | 29 |
| 6235 | 46 | 6 | 4 | 6 | 1 | 1 | 4 |
| 6236 | 34 | 5 | 2 | 8 | 1 | 1 | 2 |
| 6239 | 5 | 2 | 2 | 1 | 0 | 0 | 0 |
| TOTAL | 1841 | 171 | 117 | 34 | 25 | 224 |
Pedigree structures were defined to include the following: all known CLL cases from the UPDB that determined the high-risk status, all siblings of the CLL cases, all sampled relatives used in this study and their siblings, and all connecting relatives to the common ancestral founder/s. Column headings: Members refer to the total number of individuals in each pedigree structure; Generations is the number of generations from the pedigree founder/s; CLL indicates the number of individuals diagnosed with CLL or SLL in the pedigree; Sampled relatives indicate the number of relatives with serum used in this study; Heme malignancies represent a count of bloodline pedigree members (i.e., not including marry-ins) in each pedigree with a UCR-confirmed hematological malignancy (not including CLL/SLL); B-cell lymphoid malignancies indicate the number of bloodline pedigree members with a UCR-confirmed B-cell lymphoid malignancy (not including CLL/SLL); and Solid tumors indicate the count of UCR-confirmed solid tumors in bloodline pedigree members. Note: individuals with multiple cancers will be counted more than once