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. 2019 Feb 26;9:2753. doi: 10.1038/s41598-019-39073-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Subcellular localization of SPB2 in the normal and tumorous part of human skin tissues: (a,c) co-immunostaining with RNA Polymerase II (RNAPII) (green) and SPB2 (red) in normal and in basal cell carcinoma tissues. PC represents the phase contrast images. The N and T represent the normal and the tumorous part of the tissue, respectively. DAPI (blue) was used to visualize nuclei. Scale bars represent 180 µm (b,d) Quantitative evaluation of fluorescent intensity obtained from normal (N) and tumorous (T) part of the represented tissues. The data obtained from DAPI signal is indicated in blue, while SPB2 signal is shown in red. In each graph DAPI (blue) represents the nuclei. In the cases, when graphs of pixel intensities of DAPI and SPB2 were correlated to each other, the SPB2 showed nuclear localization (b normal samples). The inverse correlation of DAPI and SPB2 graphs reflects that SPB2 localizes in the cytoplasm (d tumorous samples).