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. 2019 Feb 26;9:2827. doi: 10.1038/s41598-019-39494-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BCAS increased Aβ oligomers with high molecular weight. (a,c) Size exclusion chromatography of PBS-soluble Aβ₄₂ from brain homogenate at week 5 and 15 post-operation. The concentration of Aβ₄₂ was measured by ELISA, and normalized to peak-concentration of low molecular weight Aβ = 100%. The molecular size of each fraction was determined by comparison with a molecular size marker. (b,d) The percentage of high and low molecular weight species in the total amount of Aβ₄₂ was determined as the area under the curve. Comparisons between groups were performed by using Student t-test. n = 4 per group.