Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 26;9:2772. doi: 10.1038/s41598-019-39395-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Circularised chromosome conformation capture using GRE viewpoints. (a) UCSC genome browser screen shot of a 2 Mb segment of chromosome 12q14.3 displaying; in green GR ChIP-seq results in Mo in the absence and in the presence of 1 μM TA, in blue H3K27ac occupancy, and in black RNA-seq data. UCSC transcripts are displayed (IRAK3 is highlighted in red) above the MACTADs and MAC(i)TADs⁴². The two lower panels display median contact intensities of the IRAK3 promoter GRE viewpoint with DNA in the 2 Mb window. Colouring is according to a normalised logarithmic scale⁸⁹ in windows of increasing size (2 kb–50 kb from top to bottom). Note the asymmetry of the signal distribution relative to the viewpoint, which spans a region that rather accurately delineates MACTAD 2675 computed by Javierre et al.⁴². (b) As (a) but for the GRE located 2 kb upstream of the PER1 gene transcription start site.