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. 2019 Feb 26;9:2772. doi: 10.1038/s41598-019-39395-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Adjacent TAD analyses. (a) Total number of MACTADs and MAC(i)TADs harbouring dynamic epigenetic regions, RNAs and GR peaks. (b) The first pair of box plots show the size distribution of all 3470 MACTADs delineated by Javierre et al.⁴² and of the intervening 3769 MAC(i)TADs, including MAC(i)TADs abutting centromeres and telomeres. The middle pair of box plots concerns TADs that harbour any dynamic feature as displayed in panel (a), and the third pair of box plots only concerns TADs bearing TA-induced features. (c) Histogram of the size distribution of the 1621 MACTADs and of 825 MAC(i)TADs bearing TA-responding features. (d) Schematic representation and size-distributions of 249 sets of four TADs that do not harbour any GR peaks themselves and that flank 249 TADs bearing at least one of the 401 MoMf-GR peaks depicted in Fig. 3b. (e) Total number of RNAs (right y-axis) and of TA-up-, and TA-down-regulated mRNAs (left y-axis) in the GR-bearing TADs and in the 249 sets of four neighbouring TADs. (f) Total number of epigenetic features (right y-axis) and of TA-up-, and TA-down-regulated histone H3-bearing epigenetic features (left y-axis) plotted as for (e).