Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 26;9:2755. doi: 10.1038/s41598-019-39370-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The localisation of IL-1β signalling molecule NFκB. (A) NFκB is translocated to the nucleus of (i) adult and (ii) fetal tenocytes following 20 minutes of exposure to IL-1β but remains in the cytoplasm in ESC-derived tenocytes. Scale bar = 20 µm. (B) Quantification of the relative nuclear fluorescent intensity demonstrates that it is significantly increased in adult and fetal tenocytes following IL-1β exposure compared to untreated cells. Error bars represent the s.e.m. of three measurements from each of three biological replicates. *p < 0.05 using an unpaired Student’s T-test. (C) NFκB translocation into the nucleus of adult tenocytes in response to 20 minutes of exposure to 17 ng/ml IL-1β can be blocked by the simultaneous addition of 100 ng/ml IL1Ra. Scale bar = 20 µm.