Table 2.
Changes in the Olink Proseek Multiplex IFN I panel in SFMCs cultured for 48 h with DMSO control, apremilast or adalimumab.
| Protein | Apremilast dose-response |
Apremilast versus DMSO |
Apremilast versus adalimumab |
||||||
|---|---|---|---|---|---|---|---|---|---|
| p.value | Bonf.adj.p | R value | p.value | Bonf.adj.p | R value | p.value | Bonf.adj.p | R value | |
| IL-12B | <0.00001 | 0.0001 | −0.27 | 0.0067 | 0.14 | −0.71 | 0.012 | 0.039 | −0.48 |
| CXCL5 | 0.0026 | 0.06 | 0.19 | 0.028 | 0.22 | 0.51 | 0.0001 | 0.0012 | 1.19 |
| CSF-1 | 0.0088 | 0.14 | −0.12 | 0.047 | 0.22 | −0.50 | 0.0073 | 0.029 | 0.38 |
| CD6 | 0.026 | 0.32 | −0.06 | 0.35 | 0.67 | −0.08 | 0.10 | 0.17 | −0.08 |
| CD40 | 0.045 | 0.43 | −0.08 | 0.72 | 0.93 | 0.04 | 0.0087 | 0.030 | 0.22 |
| MIP-1α | 0.055 | 0.44 | −0.09 | 0.22 | 0.60 | −0.35 | 0.0039 | 0.020 | 0.54 |
| CCL19 | 0.073 | 0.44 | −0.08 | 0.014 | 0.14 | −0.32 | 0.22 | 0.32 | 0.12 |
| CCL4 | 0.073 | 0.44 | −0.08 | 0.12 | 0.44 | −0.35 | 0.0023 | 0.014 | 0.56 |
| TWEAK | 0.11 | 0.50 | −0.07 | 0.13 | 0.44 | 0.14 | 0.0084 | 0.030 | −0.27 |
| OPG | 0.12 | 0.50 | −0.07 | 0.96 | 0.98 | −0.01 | 0.036 | 0.091 | 0.22 |
| IL-18R1 | 0.13 | 0.50 | −0.05 | 0.15 | 0.45 | −0.12 | 0.12 | 0.19 | −0.11 |
| TNFSF14 | 0.13 | 0.50 | −0.05 | 0.48 | 0.75 | −0.06 | 0.58 | 0.63 | 0.04 |
| TNFB | 0.14 | 0.50 | −0.04 | 0.045 | 0.22 | −0.21 | 0.060 | 0.13 | 0.08 |
| Flt3L | 0.15 | 0.51 | −0.06 | 0.98 | 0.98 | 0.00 | 0.087 | 0.16 | −0.13 |
| MMP-1 | 0.22 | 0.69 | −0.19 | 0.50 | 0.75 | 0.35 | 0.44 | 0.52 | 0.35 |
| CXCL9 | 0.25 | 0.71 | −0.07 | 0.79 | 0.95 | −0.04 | 0.0013 | 0.012 | 0.76 |
| CD244 | 0.25 | 0.71 | −0.03 | 0.74 | 0.93 | 0.02 | 0.55 | 0.62 | −0.03 |
| IL-8 | 0.31 | 0.77 | −0.02 | 0.75 | 0.93 | 0.01 | 0.0001 | 0.0012 | 0.46 |
| OSM | 0.32 | 0.77 | −0.04 | 0.50 | 0.75 | −0.11 | 0.0015 | 0.012 | 0.38 |
| EN-RAGE | 0.36 | 0.77 | −0.05 | 0.30 | 0.61 | 0.12 | 0.42 | 0.52 | −0.06 |
| MCP-1 | 0.37 | 0.77 | −0.04 | 0.30 | 0.61 | −0.20 | 0.056 | 0.13 | 0.35 |
| IL-4 | 0.37 | 0.77 | 0.03 | 0.24 | 0.60 | 0.10 | 0.32 | 0.43 | 0.07 |
| CXCL10 | 0.38 | 0.77 | −0.06 | 0.87 | 0.98 | 0.04 | 0.0024 | 0.014 | 0.98 |
| DNER | 0.40 | 0.77 | −0.02 | 0.53 | 0.77 | 0.03 | 0.42 | 0.52 | −0.04 |
| CD5 | 0.40 | 0.77 | −0.03 | 0.38 | 0.67 | 0.10 | 0.92 | 0.92 | −0.01 |
| TGFα | 0.42 | 0.77 | −0.03 | 0.25 | 0.61 | 0.08 | 0.029 | 0.081 | 0.14 |
| CCL20 | 0.44 | 0.78 | −0.03 | 0.55 | 0.77 | −0.14 | 0.0057 | 0.025 | 0.42 |
| CCL23 | 0.48 | 0.78 | −0.02 | 0.96 | 0.98 | 0.00 | 0.21 | 0.31 | 0.10 |
| uPA | 0.50 | 0.78 | −0.03 | 0.27 | 0.61 | 0.11 | 0.13 | 0.21 | 0.10 |
| IL-6 | 0.52 | 0.78 | 0.04 | 0.88 | 0.98 | 0.04 | 0.020 | 0.059 | 0.41 |
| LAP-TGFβ1 | 0.53 | 0.78 | −0.02 | 0.47 | 0.75 | −0.06 | 0.068 | 0.14 | 0.12 |
| FGF-21 | 0.55 | 0.78 | −0.02 | 0.12 | 0.44 | 0.12 | 0.73 | 0.78 | 0.02 |
| CASP-8 | 0.55 | 0.78 | −0.02 | 0.23 | 0.60 | 0.09 | 0.50 | 0.57 | −0.05 |
| CXCL1 | 0.55 | 0.78 | 0.03 | 0.30 | 0.61 | 0.19 | 0.0008 | 0.010 | 0.56 |
| CXCL11 | 0.61 | 0.82 | −0.02 | 0.64 | 0.87 | 0.07 | 0.031 | 0.081 | 0.48 |
| HGF | 0.61 | 0.82 | −0.02 | 0.015 | 0.14 | 0.46 | 0.0008 | 0.010 | −0.83 |
| MCP-3 | 0.63 | 0.82 | −0.02 | 0.76 | 0.93 | 0.03 | 0.086 | 0.16 | 0.16 |
| IL-18 | 0.66 | 0.84 | −0.01 | 0.88 | 0.98 | −0.01 | 0.30 | 0.40 | 0.04 |
| STAMPB | 0.77 | 0.92 | 0.01 | 0.059 | 0.26 | 0.06 | 0.83 | 0.85 | −0.01 |
| CXCL6 | 0.77 | 0.92 | 0.01 | 0.010 | 0.14 | 0.11 | 0.28 | 0.39 | 0.08 |
| ADA | 0.79 | 0.92 | −0.01 | 0.045 | 0.22 | 0.18 | 0.80 | 0.83 | 0.01 |
| MCP-2 | 0.84 | 0.95 | −0.01 | 0.98 | 0.98 | 0.00 | 0.0042 | 0.020 | 0.76 |
| TNFRSF9 | 0.86 | 0.95 | 0.01 | 0.14 | 0.44 | 0.11 | 0.091 | 0.16 | 0.13 |
| TRAIL | 0.88 | 0.95 | 0.00 | 0.91 | 0.98 | 0.00 | 0.37 | 0.48 | −0.04 |
| CDCP1 | 0.89 | 0.95 | 0.00 | 0.41 | 0.70 | 0.04 | 0.45 | 0.52 | −0.04 |
| VEGF-A | 0.94 | 0.96 | 0.00 | 0.044 | 0.22 | 0.16 | 0.045 | 0.11 | 0.14 |
| 4E-BP1 | 0.94 | 0.96 | 0.00 | 0.0078 | 0.14 | 0.30 | 0.062 | 0.13 | 0.16 |
| IL-10 | 1.00 | 1.00 | 0.00 | 0.37 | 0.67 | −0.08 | 0.18 | 0.28 | 0.08 |
Bold numbers; p < 0.05.
4E-BP1, 4E-binding protein 1; ADA, adenosine deaminase; Bonf.adj.p; Bonferroni adjusted p value; CASP-8, caspase-8; CDCP1, CUB domain-containing protein 1; CSF-1, colony-stimulating factor 1; DNER, Delta and Notch-like epidermal growth factor-related receptor; EN-RAGE, extracellular newly identified receptor for advanced glycation end products (RAGE)-binding protein; FGF-21, fibroblast growth factor-21; Flt3L, FMS-like tyrosine kinase 3 ligand; HGF, hepatocyte growth factor; IL, interleukin; LAP-TGFβ1, latency-associated peptide-transforming growth factor beta; MCP, monocyte chemoattractant protein; MIP-1α, macrophage inflammatory protein 1 alpha; OPG, osteoprotegerin; OSM, oncostatin M; STAMPB, signal-transducing adaptor molecule-binding protein; TGFα, transforming growth factor alpha; TNFβ, tumor necrosis factor beta; TNFRSF9, tumor necrosis factor receptor superfamily member 9; TNFSF14, TNF superfamily member 14; TRAIL, TNF-related apoptosis-inducing ligand; TWEAK, tumor necrosis factor-like weak inducer of apoptosis; uPA, urokinase-type plasminogen activator; VEGF-A, vascular endothelial growth factor A.