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. 2019 Feb 22;10:2041731419827922. doi: 10.1177/2041731419827922

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Diagram demonstrating the collaboration between modelling and experimentation, culminating in the development of protocols for large-scale tissue engineering informed by experiment-parameterised models. Calibration experiments can be used to inform a mathematical model, which can then be parameterised to the experimental measurements. The parameterised model can then provide predictions about the effect of different operating conditions on culture growth, proposing a range which improves cell yield. Upon an experimental validation of these suggestions and implementing any necessary adjustments, new robust and more efficient protocols for bone tissue engineering are developed.