Table 1.
Passive, electrotonic properties of hippocampal granule cells
| Passive properties | Sham DCX+ |
Sham DCX− |
MCAO DCX+ |
MCAO DCX− |
M-W U test |
M-W U test |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sham DCX+ vs MCAO DCX+ |
Sham DCX− vs MCAO DCX− |
|||||||||||||
| n/N | Median (IQR) | n/N | Median (IQR) | n/N | Median (IQR) | n/N | Median (IQR) | p | U | η2 | p | U | η2 | |
| Vrest (mV) | 33/11 | −65 (31.1) | 18/9 | −91.4 (3.7) | 43/17 | −80.7 (32.7) | 20/5 | −86.2 (6.1) | 0.016 | 480.5 | 7.7% | <0.0001 | 36 | 47.9% |
| Rinput (GΩ) | 33/11 | 3.52 (4.0) | 18/9 | 0.55 (0.29) | 43/17 | 1.56 (2.7) | 20/5 | 0.92 (0.4) | 0.002 | 418 | 12.4% | 0.001 | 66 | 30.0% |
| Cm (pF) | 33/11 | 5.5 (17.2) | 18/9 | 36.8 (32.6) | 43/17 | 19.3 (22.5) | 19/5 | 59.0 (31.3) | 0.025 | 496 | 6.7% | 0.004 | 77 | 22.7% |
| τm (ms) | 30/11 | 116.5 (100.2) | 18/9 | 26.3 (9.4) | 41/17 | 42.8 (34.6) | 20/5 | 30.6 (13.9) | <0.0001 | 176 | 37.3% | 0.593 | 161 | 0.8% |
| Cell maturation | 33/11 | Fraction (%) | 18/9 | Fraction (%) | 43/17 | Fraction (%) | 20/5 | Fraction (%) | 0.025 | 569 | 6.8% | 0.010 | 93 | 23.1% |
| Immature | 31/33 (94%) | 0/18 (0%) | 32/43 (74%) | 5/20 (25%) | ||||||||||
| Intermediate | 2/33 (6%) | 10/18 (56%) | 9/43 (21%) | 13/20 (65%) | ||||||||||
| Mature | 0/33 (0%) | 8/18 (44%) | 2/43 (5%) | 2/20 (10%) | ||||||||||
M-W, Mann–Whitney; n/N–, number of cells/number of mice. Summary of electrotonic cell properties in the three recorded groups. Resting potential was determined immediately after whole-cell access. Cell maturation group was defined based on input resistance as follows: immature cells had Rinput of ≥1 GΩ, intermediately mature cells had a Rinput <1 GΩ but >0.5 GΩ, and mature cells had an Rinput of ≤0.5 GΩ. The statistical unit is n.