Table 3.
Excitatory synaptic properties of hippocampal granule cells
| Synaptic properties | Sham DCX+ |
Sham DCX− |
MCAO DCX+ |
MCAO DCX− |
M-W U test |
M-W U test |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sham DCX+ vs MCAO DCX+ |
Sham DCX− vs MCAO DCX− |
|||||||||||||
| n/N | Median (IQR) | n/N | Median (IQR) | n/N | Median (IQR) | n/N | Median (IQR) | p | U | η2 | p | U | η2 | |
| sEPSC amplitude (pA) | 6/5 | 5.3 (2.3) | 6/3 | 8.5 (2.7) | 12/9 | 7.4 (2.5) | 17/5 | 7.2 (1.3) | 0.018 | 11 | 32.2% | 0.256 | 34 | 6.4% |
| sEPSC IEI (ms) | 3084 (2605) | 673 (1216) | 1626 (4381) | 1489 (1706) | 0.75 | 32 | 0.8% | 0.052 | 23 | 17.5% | ||||
| mEPSC amplitude (pA) | 6/4 | 5.1 (1.8) | 6/3 | 6.3 (1.5) | 9/7 | 8.0 (2.3) | 15/5 | 6.4 (2.3) | 0.002 | 2 | 62.0% | 0.569 | 37 | 1.9% |
| mEPSC IEI (ms) | 1742 (4274) | 734 (716) | 1403 (1839) | 1546 (2079) | 0.328 | 18 | 8.0% | 0.008 | 12 | 33.0% | ||||
| LPP facilitation | 7/6 | 1.57 (1.05) | 16/7 | 1.53 (1.36) | 0.076 | 29 | 14.8% | |||||||
| In cells with mature AP | Sham DCX− vs MCAO DCX+ | Sham DCX− vs MCAO DCX− | ||||||||||||
| sEPSC amplitude (pA) | 6/3 | 8.5 (2.7) | 7/6 | 7.6 (2.3) | 16/5 | 7.2 (1.0) | 0.445 | 15 | 6.1% | 0.231 | 31 | 7.5% | ||
| sEPSC IEI (ms) | 673 (1216) | 1495 (848) | 1496 (1756) | 0.138 | 10 | 20.6% | 0.049 | 21 | 18.9% | |||||
| mEPSC amplitude (pA) | 6/3 | 6.3 (1.5) | 6/5 | 8.1 (1.0) | 14/5 | 6.4 (2.3) | 0.009 | 2 | 59.7% | 0.718 | 37 | 0.9% | ||
| mEPSC IEI (ms) | 734 (716) | 1418 (1753) | 1421 (2239) | 0.310 | 11 | 11.4% | 0.012 | 12 | 32.2% | |||||
M-W, Mann–Whitney; n/N = number of cells/number of mice. Summary of excitatory synaptic properties in the four recorded groups. sEPSCs were measured with 10 μm PTX added in the bath solution, while mEPSCs with 10 μm PTX and 1 μm TTX in the bath solution. The statistical unit is n.