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. 2019 Feb 19;6(1):ENEURO.0308-18.2018. doi: 10.1523/ENEURO.0308-18.2018

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Copyright © 2019 Dermentzaki et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — Ripk3^−/−MNs are resistant to Tg SOD1^G93A astrocyte-mediated toxicity. MNs, isolated from E12.5 Ripk3^+/+or Ripk3^−/−mice, were co-cultured on primary astrocyte monolayers from Tg SOD1^G93A or NTg mice for 7 d. A, Representative images of MNs assessed using SMI32 immunolabeling. Scale bar: 50 μm. B, Quantification of MN number. Ripk3^+/+MN number was significantly reduced on SOD1^G93A astrocytes (p = 0.0013) compared to NTg. Ripk3^−/−MN number did not differ between NTg or SOD1^G93A astrocytes and was significantly increased (p = 0.0370) compared to Ripk3^+/+ MN number on SOD1^G93A astrocytes. Results are presented as a mean ± SEM. Statistical analysis was performed via two-way ANOVA; n = 3 biological replicates per genotype. *p ≤ 0.05; **p ≤ 0.01.