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. 2019 Feb 19;6(1):ENEURO.0308-18.2018. doi: 10.1523/ENEURO.0308-18.2018

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Copyright © 2019 Dermentzaki et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Onset and survival in Tg SOD1^G93A;Ripk3^−/− mice. Mice were separated by genotype and sex for onset (%) and survival (%), and data were plotted as Kaplan–Meier curves. A, Onset in Tg SOD1^G93A;Ripk3^−/− (median = 155) and Tg SOD1^G93A;Ripk3^+/+ (median = 151), p = 0.06; male and female mice. B, Onset in Tg SOD1^G93A;Ripk3^−/− (median = 155) and Tg SOD1^G93A;Ripk3^+/+ (median = 152), p = 0.005; male mice. C, Onset in Tg SOD1^G93A;Ripk3^−/− (median = 148) and Tg SOD1^G93A;Ripk3^+/+ (median = 155), p = 0.836; female mice. D, Survival in Tg SOD1^G93A;Ripk3^−/− (median = 169) and Tg SOD1^G93A;Ripk3^+/+ (median = 163), p = 0.145; male and female mice. E, Survival in Tg SOD1^G93A;Ripk3^−/− (median = 178) and Tg SOD1^G93A;Ripk3^+/+ (median = 157), p = 0.017; male mice. F, Survival in Tg SOD1^G93A;Ripk3^−/− (median = 163) and Tg SOD1^G93A;Ripk3^+/+ (median = 170), p = 0.340; female mice. For A, D, 10 Tg SOD1^G93A;Ripk3^+/+ mice and 12 Tg SOD1^G93A;Ripk3^−/− mice. For B, E, 5 Tg SOD1^G93A;Ripk3^+/+ mice and 7 Tg SOD1^G93A;Ripk3^−/− mice. For C, F, 5 Tg SOD1^G93A;Ripk3^+/+ mice and 5 Tg SOD1^G93A;Ripk3^−/− mice. Statistical analysis was performed via log-rank Mantel–Cox test.