Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 20;30(10):1369–1386. doi: 10.1089/ars.2017.7408

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2019, Mary Ann Liebert, Inc., publishers

PMC Copyright notice

FIG. 4. — Chemical-proteomic platforms for general cysteine PTMs. (A) Structures of ICAT reagents. (B) OxICAT is a modified ICAT technology for oxidative cysteine PTMs. (C) A quantitative proteomic platform, isoTOP-ABPP, enables comprehensive identification and quantification of cysteine PTMs. (D) Caged electrophilic probes are developed to achieve in situ labeling of cysteine and analysis of cysteine PTMs within a physiological context. CBK1, caged α-bromomethylketone alkyne; IAA, idoacetamide alkyne; ICAT, isotope-coded affinity tags; isoTOP-ABPP, isotopic tandem orthogonal proteolysis activity-based protein profiling; LC-MS/MS, liquid chromatography-tandem mass spectrometry; OxICAT, oxidative isotope-coded affinity tag; TCEP, tris(2-carboxyethyl)phosphine; UV, ultraviolet. Color images are available online.