Figure 1. . Amantadine pharmacokinetics.

Amantadine pharmacokinetic parameters in normal healthy adults in fed or fasted state. Urinary acetylamantadine concentrations were determined by LC–MS/MS technique up to 12 h postamantadine ingestion. Values are mean ± SEM and are expressed as ng/ml. The p < 0.05 was considered as significantly different fed versus fasted state.

AUC: Area under the curve; CL_p/f: Apparent total clearance of the drug from plasma after oral administration; C_max: Maximum (or peak) serum concentration that a drug achieves; t_1/2: Time required for a quantity to reduce to half its initial value; T_max: Time after administration of a drug when the maximum plasma concentration is reached; V_d/f: Apparent volume of distribution.