Table 1. . Deregulation of eukaryotic initiation factors in skin cancer.

Factor	Deregulation in skin cancer	Ref.
eIF1	N/A	N/A
eIF1A	Mutations associated with metastasis in uveal melanoma	[147–149]
eIF2α	Inhibition via phosphorylation protects from transformation	[150,153–155]
eIF2β	N/A	N/A
eIF2γ	Transiently upregulated	[156]
eIF2B	Inhibition by p-eIF2α	[59]
eIF3a	Increased expression	[157]
eIF3b	N/A	N/A
eIF3c	Decreased expression	[158]
eIF3d	KD suppresses proliferation	[159]
eIF3e	N/A	N/A
eIF3f	Decreased expression	[160,161]
eIF3g	N/A	N/A
eIF3h	N/A	N/A
eIF3i	Increased expression	[162]
eIF3j	N/A	N/A
eIF3k	N/A	N/A
eIF3l	N/A	N/A
eIF3m	N/A	N/A
eIF4A1	Increased expression	[163]
PDCD4	Decreased expression - Inhibition via phosphorylation	[164–167]
eIF4B	Enhancement via phosphorylation	[168,169]
eIF4E	Increased expression & phosphorylation	[170–174]
4E-BPs	Hyperphosphorylation	[175–178]
eIF4G	N/A	N/A
eIF4F complex	Persistent formation leads to resistance to treatment	[178]
eIF5A1	Inhibition impairs melanoma growth	[179]
eIF5A2	Increased expression	[180]
eIF5B	N/A	N/A
eIF6	Increased expression	[181]