Figure 4.
NCoR1 deficiency compromises the long-term lymphoid-repopulation capacity of HSCs. (A) Schematic diagram for serial competitive transplantation assay with control and Vav-iCre+, NCoR1f/f BM cells. (B) Percentage of donor-derived cells (total cells) in PB of primary recipient mice (n = 5 per group) at the indicated time points. Percentage of donor-derived T (CD3+) cells (C), B (B220+) cells (D), and myeloid (CD11b+) cells (E) in the PB of recipient animals (n = 5 per group) at the indicated time points. (F) Percentage of donor-derived cells (total cells, LSK cells, LT-HSCs, and ST-HSCs) in BM of primary recipient mice (n = 5 per group) 16 weeks after transplantation. Data are mean ± standard error of the mean from 3 independent experiments. **P < .01, ***P < .001. 1st, first competitive transplantation; 2nd, second competitive transplantation.