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. 2019 Feb 26;3(4):658–669. doi: 10.1182/bloodadvances.2018029983

Figure 2.

Figure 2.

Pretreatment of baboons with 3G3 antibody reduced coagulation activation and prevented coagulopathy following a lethal dose of heat-inactivated S aureus injection. Time course dynamics of clotting times aPTT (A) and PT (B), and plasma hemostatic biomarkers FXIIa-AT (C), FXIIa-C1 inhibitor complexes (D), kal-AT complexes (E), kal-C1 inhibitor complexes (F), FXIa-AT complexes (G), FIXa-AT complexes (H), FVIIa-AT (I), FXa-AT (J), TAT complexes (K), and TF mRNA (L) in leukocytes. Data are represented as mean ± standard error of the mean (SEM). Same time points are compared between LDSA and LDSA plus 3G3-pretreated (LDSA + 3G3) animals using 2-tailed Student t test. *P < .05, **P < .01, ***P < .001. AT, antithrombin; kal, kallikrein; mRNA, messenger RNA; TAT, thrombin-antithrombin.