Figure 1.

ATL cells are resistant to Tax-induced senescence. T cells were transduced with the HTLV-1 oncogenic protein Tax and an EGFP Tax-reporter plasmid¹⁴ and allowed to grow undisturbed for 7 to 10 days. Transduced T cells were monitored for proliferation in semisolid media, as described in “Materials and methods.” This experiment was repeated 3 times; representative images acquired using a 10× objective are shown.