Table 2.
Results From IVGTT and Arginine Stimulation
|
Groups
|
P Values
|
|||||
|---|---|---|---|---|---|---|
| Nonobese (n = 8) | Obese (n = 10) | RYGB (n = 12) | Obese vs Nonobese | RYGB vs Nonobese | RYGB vs Obese | |
| IVGTT | ||||||
| AIRg, mL−1 × μU × min | 356 ± 85 | 445 ± 60 | 492 ± 87 | 0.73 | 0.46 | 0.90 |
| SI, mL × μU−1 × min−1 | 8.0 ± 1.6 | 6.6 ± 1.4 | 5.4 ± 0.6 | 0.70 | 0.29 | 0.75 |
| DI | 2016 ± 175 | 2684 ± 716 | 2685 ± 577 | 0.74 | 0.80 | 0.99 |
| β-cell glucose sensitivity | ||||||
| Insulin | 0.167 ± 0.051 | 0.198 ± 0.035 | 0.097 ± 0.018 | 0.80 | 0.34 | 0.09 |
| C-peptide | 0.017 ± 0.003 | 0.020 ± 0.002 | 0.013 ± 0.002 | 0.69 | 0.51 | 0.11 |
| Arginine stimulation | ||||||
| Peak glucose, mg × dL−1 | 512 ± 23 | 478 ± 17 | 474 ± 13 | 0.38 | 0.29 | 0.99 |
| AinsRmax, μU × mL−1 | 146 ± 41 | 202 ± 31 | 191 ± 32 | 0.52 | 0.64 | 0.97 |
| AglucRmax, pg × mL−1 | 34 ± 6 | 37 ± 5 | 37 ± 7 | 0.95 | 0.93 | 0.99 |
Data are presented as mean ± SE. P values are shown for between-group comparisons.
Abbreviation: AglucRmax, maximal glucagon secretion quantified after arginine stimulation; AIRg, acute insulin response to glucose.