Fig. 4.

a Right ventricular systolic pressure (RVSP) was determined as stated in the Materials and Methods section in mice after 24 weeks in WT and SmPparγ^−/− mice subjected to LFD or HFD. In a two-factor ANOVA with interaction the diet had the predominant impact with p = 0.01. The effect of genotype did not reach significance (p = 0.143), and there was no interaction (p = 0.754). b Systemic arterial pressure (SAP, mmHg) in mice after 24 weeks in WT and SmPparγ^−/− mice subjected to LFD or HFD is shown. c Heart rate (beats per minute, bpm) in mice after 24 weeks in WT and SmPparγ^−/− mice subjected to LFD or HFD (n = 8–15 per group). d Analyses of correlation between right ventricular systolic pressure (RVSP) and area under the curve (AUC) of absolute glucose levels in ITT determined at the 24 week time point for all analyzed animal groups. Pearson r = 0.45, p < 0.01