Table 3.
Genomic, mRNA and transcriptomic GC contents in the investigated human conditions and other species
| Species | Genomic GC% | mRNA GC% | Transcriptomic GC% | ∆GC%(mRNA−Genomic) | ∆GC%(Transcriptomic−mRNA) |
|---|---|---|---|---|---|
| H. sapiens DS-AMKL | 40.89 | 48.80 | 48.21 | 7.91 | − 0.59 |
| H. sapiens MK | 49.27 | 7.91 | 0.47 | ||
| H. sapiens Hippocampus | 48.83 | 48.85 | 7.94 | 0.03 | |
| H. sapiens Brain | 48.92 | 7.94 | 0.09 | ||
| D. rerio Brain | 36.63 | 45.70 | 45.40 | 9.08 | − 0.30 |
| C. elegans | 35.44 | 42.21 | 43.22 | 6.77 | 1.00 |
| S. cerevisiae | 38.30 | 39.63 | 40.21 | 1.34 | 0.58 |
| E. coli | 50.79 | 51.99 | 52.13 | 1.20 | 0.15 |
Genomic GC%: percentage of G (guanine), C (cytosine) and S (G or C, present only in H. sapiens and D. rerio assemblies); for H. sapiens the mean GC content between male and female genomes was used; mRNA GC%: percentage of G and C in the analysed messenger RNA set having an expression value together with mRNA sequences available (see “Methods” section for details); transcriptomic GC%: percentage of G and C in the sum of each mRNA GC count multiplied by its mean expression value for each biological condition; ∆GC%(mRNA−Genomic): difference between mRNA and genomic GC%; ∆GC%(Transcriptomic−mRNA): difference between transcriptomic and mRNA GC%