Table 2.
Studies investigating substrate utilisation during exercise matched for relative intensities in hypoxia compared with normoxia
| Study | Participants | Study design | Type of hypoxia | Altitude (m) | Duration of exposure | Absolute substrate use (g.min−1) | Relative substrate use (%) | ||
|---|---|---|---|---|---|---|---|---|---|
| CHO oxidation | Fat oxidation | CHO oxidation | Fat oxidation | ||||||
| Braun et al. (2000) [11] | 15 (females) | 30 min cycling at 65% relative VO2max | TA | 4300 | 10 days | SL:1.95 ± 0.11 CH:1.22 ± 0.09 |
NM | NM | NM |
| Lundby and Van Hall (2002) A [22] | 8 (male = 6, female = 2) | 60 min cycling at 50% relative VO2max | NH | 4100 | 70 min | SL: 2.00 ± 0.20 AH: 1.70 ± 0.10 |
SL: 0.30 ± 0.01 AH: 0.20 ± 0.02 |
SL: 73.90 ± 2.00 AH: 75.50 ± 1.90 |
SL: 26.10 ± 2.00 AH: 24.50 ± 1.90 |
| Lundby and Van Hall (2002) B [22] | 8 (male = 6, female = 2) | 60 min cycling at 50% relative VO2max | TA | 4100 | 10 days | SL: 2.00 ± 0.20 CH: 1.70 ± 0.02 |
SL: 0.30 ± 0.01 CH: 0.30 ± 0.02 |
SL: 73.90 ± 2.00 CH: 74.40 ± 1.50 |
SL: 26.10 ± 2.00 CH: 25.60 ± 1.50 |
| Matu et al. (2017) A [6] | 12 (males) | 60 min walking at 50% relative VO2max | NH | 2150 | 5 h | SL: 1.56 ± 0.35 AH: 1.18 ± 0.34 |
SL: 0.41 ± 0.18 AH: 0.44 ± 0.21 |
SL: 62.80 ± 13.30 AH: 55.10 ± 18.90 |
SL: 37.20 ± 13.30 AH: 44.90 ± 18.90 |
| Matu et al. (2017) B [6] | 12 (males) | 60 min walking at 50% relative VO2max | NH | 4300 | 5 h | SL: 1.56 ± 0.35 AH: 0.87 ± 0.37 |
SL: 0.41 ± 0.18 AH: 0.38 ± 0.19 |
SL: 62.80 ± 13.30 AH: 50.80 ± 19.80 |
SL: 37.20 ± 13.30 AH: 49.20 ± 19.80 |
| Morishima et al. (2014) A [55] | 8 (males) | 30 min cycling at 60% relative VO2max | NH | 2700 | 7.5 h | NM | NM | SL: 60.00 ± 7.80 AH: 93.70 ± 2.50 |
SL: 40.00 ± 7.80 AH: 6.30 ± 2.50 |
| O’Hara et al. (2017) B [5] | 7 (males) | 105 min cycling at ~ 74% relative VO2max | HH | 3375 | 155 min | SL: 2.64 ± 0.50 AH: 1.47 ± 0.62 |
SL: 0.38 ± 0.19 AH: 0.63 ± 0.25 |
SL: 73.10 ± 13.10 AH: 48.80 ± 18.90 |
SL: 26.90 ± 13.10 AH: 51.20 ± 18.90 |
| Peronnet et al. (2006) [4] | 5 (males) | 80 min cycling at 77% relative VO2max | HH | 4300 | 110 min | SL:3.25 ± 0.13 AH:2.67 ± 0.10 |
SL:0.37 ± 0.05 AH: 0.10 ± 0.03 |
SL:78.10 ± 1.80 AH: 92.00 ± 2.10 |
SL: 21.90 ± 1.80 AH: 8.00 ± 2.10 |
Values presented as mean ± SD. HH hypobaric hypoxia, NH normobaric hypoxia, TA terrestrial altitude, SL sea level, AH acute hypoxia, CH chronic hypoxia, CHO carbohydrate, NM not measured. A and B refer to the different trial arms of each study