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. 2019 Feb 27;16:15. doi: 10.1186/s12986-019-0341-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — SBH attenuates histological alterations in the liver, kidney, heart and lung of LPS-induced rats. Microscopic examination of H&E-stained sections of the control and 9.3 g/kg SBH-supplemented rats revealed normal histological structure of the liver, kidney, heart and lung. In contrast, liver sections of the LPS-induced rats showed an increase in lymphocytes (arrow heads) and neutrophils (arrows) infiltration and necrosis (circle). LPS-induced rats received 4.6 or 9.3 g/kg SBH showed a significant reduction in lymphocyte (arrow heads) and neutrophils (arrows) infiltration and improved liver histology. The kidney of LPS-induced rats showed infiltration of lymphocytes (arrow heads) and neutrophils (arrows), renal granuloma (circle) and degeneration of tubular cells. SBH-supplemented LPS-induced rats showed significantly reduced infiltration of lymphocytes (arrow heads) and neutrophils (arrows). The heart sections of LPS-induced rats showed degeneration of cardiomyocytes and infiltration of lymphocytes (arrow heads) and neutrophils (arrows), and the lung sections revealed edema, alveolar wall thickness and lymphocytes (arrow heads) and neutrophils (arrows) infiltration. Treatment of the LPS-induced rats with 4.6 or 9.3 g/kg SBH resulted in reduced infiltration of lymphocytes (arrow heads) and neutrophils (arrows) and improved histological appearance of the heart and lung tissues